ARCA (Antiretroviral Resistance Cohort Analysis) is a public database developed as a tool for investigating resistance to drugs used against the human immunodeficiency virus (HIV) (antiretrovirals).

The database contains the patients’ treatment data together with the variations in the viral genome and the corresponding inferred susceptibility to the currently licensed antiretrovirals, as well as the time course of the reference surrogate markers of the course of the infection (plasma HIV RNA load and CD4 cell counts).

ARCA is being fed with data provided from different organizations, mainly universities and public health services, and can be freely consulted in the public area to access descriptive statistics on antiretroviral resistance, use a genotype interpretation system (AntiRetroScan) and a test version of a novel data-driven model for prediction of response to treatment.